The Nanomizer is essentially a large brass crucible or chamber into which molten metals are poured to create the tiny particles. The special atmosphere that is developed inside the chamber using proprietary technology causes this conversion - gases are spun at high speed and the metal particles are formed in the region of zero centrifugal force.
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The mixture was then co-ground calculating the amount of free drug (NI) concentration in the by a roll mill (R3-1R, Kodaira Seisakusho Co., Ltd.). The dispersions, according to the following equations.24,25) grinding part consisted of three rollers and the rotating veloci- ty ratios for each roller were fixed as 1 : 2.5 : 5.8.
Nanomilling is the process by which the particle size of an API is reduced in a liquid vehicle (typically aqueous) via grinding using polymeric or ceramic media. Nanomilling is a proven, commercially validated process for formulating poorly water-soluble APIs.
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The Nanomizer process is the first commercial technology for producing uniform nanoparticles. It is suited to a range of materials and can produce controlled morphologies and microstructures. Applications and potential applications for materials produced via the Nanomizer process are mentioned.
In our previous study, a Nanomizer ® was used. In the current study, we initially checked the effect of the Microfluidizer ® on the physicochemical properties of the NI–LN suspensions. The mean particle size and zeta potential of the NI–LNs were measured using an electrophoretic light scattering (ELS) photometer (Zetasizer Nano ZS ...
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The Nanomizer and the high-pressure jet mill disperse the CNTs using a turbulent flow. The probe sonicator disperses the CNTs through cavitation. The remaining methods use mechanical forces with or without the presence of grinding media (balls or beads).
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The Nanomizer and high-pressure jet mill methods were among the methods to exhibit the highest G/D ratios along with cone milling, ball milling and high shear batch disperser.
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The Nanomizer and the high-pressure jet mill disperse the CNTs using a turbulent flow. The probe sonicator ... mechanical forces with or without …
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Nanonization refers to the creation or manipulation of particles ranging in size from 1 nanometer (nm) to 100 nm. Much of biology happens at nanoscale. Nanoparticles can be fabricated using bottom-up or top-down methods. Bottom-up nanofabrication refers to building particles using chemistry, while top-down describes grinding or milling.
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The mechanical grinding is to mill a material to be milled by: introducing milling media, such as balls or beads, and the material to be milled into a vessel; and rotating the vessel. For example, there has been known a process in which particles of a slightly soluble crystalline drug in the form of a mixed solution with a surface modifier is ...
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The use of Nifedipine (NI), a dihydropyridine calcium channel blocker, is limited due to its poor aqueous solubility. However, NI loaded solid-lipid nanoparticles (NI-SLN) are known to exhibit suitable pharmacokinetic properties and good biocompatibility. The present investigation was designed to evaluate the effects of NI-SLN on glucose homeostasis, lipid metabolism and liver …
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