In an attempt to improve the bioavailability of EMD 57033, a poorly water-soluble calcium sensitizing agent, Vogt et al. found that co-grinding a mixture of EMD 57033 with lactose and hydroxypropylmethyl cellulose using a fluid energy mill was more effective than micronizing the drug alone or spray drying a nanosuspension of the drug.
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Comminution or grinding may be defined as the process of particle size reduction. Large particles take a longer time for complete extraction than small ones and large differences in particle size thus slow down the extraction process. Several types of machines are available for grinding crude drugs: 1.
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drugs [1]. e. Decoction: this method is used for the extraction of the water soluble and heat stable constituents from crude drug by boiling it in water for 15 minutes, cooling, straining and passing sufficient cold water through the drug to produce the required volume [2]. f. Infusion: It is a dilute solution of the readily soluble
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The invention discloses a kind of medicine pill being used for the treatment of hepatitis B type liver cirrhosis, it is characterized in that, comprise following crude drug: Radix Sophorae Flavescentis, Cacumen Securinegae Suffruticosae, Radix Stephaniae Tetrandrae, Semen Cuscutae, Herba Silybi mariani, Fructus Schisandrae Chinensis, Herba Sedi, Fructus Ligustri Lucidi, stricture of …
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In the imports, the most significant products are platinum and platinum alloys, unwrought or in powder form, the crude petroleum oils, nickel ores and concentrates and electricity.In the period January-November 2012, the most important export partners were the EU-27 countries (62.5%) and the West Balkan countries (24.6%), while the most important import partners were the EU …
The invention discloses a kind of electrician silicon powder grinding devices, including board, grinding groove is offered at the top of the board, the back side of the board is welded with upper frame, the upper frame has been symmetrically mounted at the bottom of telpic cylinder, the bottom of the telpic cylinder is equipped with curved frame, motor is installed in the middle …
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All particles of iron will thus be removed. Garbling is absolutely essential for producing a clean drug sample and to minimize damage to the grinding machine and to the dies and punches of the tablet machine by which some of the powdered crude drugs may be compressed into tablets. 4. QUALITY CONTROL:
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Drying also facilitates pulverizing or grinding of a crude drug. In certain drugs, some special methods are required to be followed to attain specific standards, e.g. fermentation in case of Cinnamomum zeylanicum bark and gentian roots.
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Phenolic content of crude drugs on the other hand is the lowest if it is dried at 60 °C. Drying at 40 °C, 80 °C and 100 °C produce crude drug with higher phenolic content compared to those dried at 60 °C. This may associated with the activity of peroxidase that has optimal activity at 60° C.
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Pin mill is a kind of milling equipment that can break up cellular materials selectively without damaging the starch granules. It consists of two horizontal steel plates with vertical projections arranged in concentric circles on opposing faces and becomes more closely spaced towards the periphery. Pin mill...
Machines are available for grinding crude drugs: 1. Hammer mill. 2. Knife mill; 3. Tooth mill; 4. Blender. 5. Morter and pestle 12 By Erhirhie Earnest O. Machines are available for grinding ...
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Nanosizing is a suitable method to enhance the dissolution rate and therefore the bioavailability of poorly soluble drugs. The success of the particle size reduction processes depends on critical factors such as the employed technology, equipment, and drug physicochemical properties. High pressure homogenization and wet bead milling are standard …
The goal of this study was to identify and compare the main biomarkers of Taxillus chinensis from different hosts. A metabolomics approach utilizing ultra-pressure liquid chromatography coupled with tandem mass spectrometry (UPLC-MS), including cluster analysis, sample correlation analysis and orthogonal partial least squares discriminant analysis, was …
In these milling operations, the dried crude drug may be cut by sharp blades (cutter mill), impacted by hammers or crushed/compressed by the application of pressure (roller mill, pestle and mortar). As a limited amount of energy is imparted, the milled particles remain relatively coarse.
Manual grinding mills are generally for the small-scale processor. They tend to be based on circular stones or plates that are turned against each other, crushing the peppercorns between the stones. With a good mill, an experienced processor can hand grind about 20kg pepper in an 8 hour day. However, this is very labour intensive, boring work.
A ball mill also known as pebble mill or tumbling mill is a milling machine that consists of a hallow cylinder containing balls; mounted on a metallic frame such that it can be rotated along its longitudinal axis. The balls which could be of different diameter occupy 30 – 50 % of the mill volume and its size depends on the feed and mill size.
A crude drug is naturally occurring drug with pharmacologically active ingredients in an unrefined state, requiring no additional processing for use. An example is ginseng root; patients can consume fresh or dried roots straight in addition to grinding them into powder for use in capsules, teas, and other preparations. The root is ready to use […]
•It is also necessary to protect the drug against insect attack. 4. Grinding of crude drugs •Regardless of whether the crude drug is to be used for isolation of a pure compound or for manufacture of a simple preparation, the first operation that must be performed is grinding of the plant material to a powder of suitable particle size.
